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Other than Wrong-positive final results, heterophile antibodies could potentially cause falsely reduced benefits whenever they bind to the variable regions from the seize antibody, mimicking the antigen to get calculated and protecting against troponin from binding.[89] The most often applied approach for minimizing the affect of HAMA on industrial immunoassays is definitely the addition of non-immune mouse immunoglobulin (IgG).

A meta-Examination of 14 scientific studies showed the specificity of the elevated troponin about the 99th percentile was drastically reduced in patients with CKD. It really is very important to learn Should the troponins are trending as time passes in these individuals.[seventy three] The troponin levels in patients with CKD usually are steady, so a rise and slide of your troponin would be a lot more indicative of a cardiac explanation for the elevated troponin.

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